{"id":23993,"date":"2026-04-01T15:16:47","date_gmt":"2026-04-01T19:16:47","guid":{"rendered":"https:\/\/vitamins.vitanetonline.com\/?p=23993"},"modified":"2026-04-01T15:16:47","modified_gmt":"2026-04-01T19:16:47","slug":"the-epigenetics-of-osteoporosis-how-undermethylation-impacts-bone-density","status":"publish","type":"post","link":"https:\/\/vitamins.vitanetonline.com\/index.php\/the-epigenetics-of-osteoporosis-how-undermethylation-impacts-bone-density\/","title":{"rendered":"The Epigenetics of Osteoporosis: How Undermethylation Impacts Bone Density"},"content":{"rendered":"<p><img decoding=\"async\" class=\"aligncenter size-large wp-image-23994\" src=\"https:\/\/vitamins.vitanetonline.com\/wp-content\/uploads\/2026\/04\/undermethylationandboneloss-1024x559.png\" alt=\"Methylation plays a role in Bone building and Bone Loss!\" width=\"1024\" height=\"559\" srcset=\"https:\/\/vitamins.vitanetonline.com\/wp-content\/uploads\/2026\/04\/undermethylationandboneloss-1024x559.png 1024w, https:\/\/vitamins.vitanetonline.com\/wp-content\/uploads\/2026\/04\/undermethylationandboneloss-300x164.png 300w, https:\/\/vitamins.vitanetonline.com\/wp-content\/uploads\/2026\/04\/undermethylationandboneloss-768x419.png 768w, https:\/\/vitamins.vitanetonline.com\/wp-content\/uploads\/2026\/04\/undermethylationandboneloss-1536x838.png 1536w, https:\/\/vitamins.vitanetonline.com\/wp-content\/uploads\/2026\/04\/undermethylationandboneloss-2048x1117.png 2048w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/p>\n<h2><strong>Does Under-Methylation cause bone loss?<\/strong><\/h2>\n<p><span style=\"font-weight: 400;\">Yes, <\/span><b>undermethylation<\/b><span style=\"font-weight: 400;\"> (or hypomethylation) can contribute to bone loss and an increased risk of osteoporosis. This happens through several biological pathways, most notably involving the buildup of homocysteine and the epigenetic regulation of bone cells.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The link between poor methylation and bone health is primarily driven by three factors:<\/span><\/p>\n<h3><b>1. The Homocysteine Connection<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">In a state of undermethylation, the body often struggles to convert <\/span><b>homocysteine<\/b><span style=\"font-weight: 400;\"> back into methionine. This leads to elevated homocysteine levels (<\/span><b>hyperhomocysteinemia<\/b><span style=\"font-weight: 400;\">), which is a well-documented risk factor for bone loss.<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Collagen Weakening:<\/b><span style=\"font-weight: 400;\"> Homocysteine interferes with the &#8220;cross-linking&#8221; of collagen fibers. Since collagen provides the flexible &#8220;rebar&#8221; that keeps bones from being brittle, this interference makes the bone matrix structurally weaker, even if density looks normal on a scan.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Reduced Blood Flow:<\/b><span style=\"font-weight: 400;\"> High homocysteine can damage small blood vessels (microvasculature) within the bone, depriving bone tissue of necessary nutrients and oxygen.<\/span><\/li>\n<\/ul>\n<h3><b>2. Epigenetic &#8220;Switching&#8221; (DNA Methylation)<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">Methylation acts like a &#8220;mute&#8221; button for certain genes. When you are undermethylated, that mute button isn&#8217;t pressed, allowing specific genes to become overactive:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>RANKL Overexpression:<\/b><span style=\"font-weight: 400;\"> Research shows that <\/span><b>hypomethylation<\/b><span style=\"font-weight: 400;\"> (lack of methyl groups) on the promoter of the <\/span><b>RANKL<\/b><span style=\"font-weight: 400;\"> gene causes it to stay &#8220;turned on.&#8221; RANKL is a protein that stimulates <\/span><b>osteoclasts &#8211; <\/b><span style=\"font-weight: 400;\">the cells responsible for breaking down and resorbing bone.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Osteoclast Overactivity:<\/b><span style=\"font-weight: 400;\"> When RANKL is too active, bone is broken down faster than the body can rebuild it (osteoblast activity), leading to a net loss of bone mineral density.<\/span><\/li>\n<\/ul>\n<h3><b>3. Nutritional Deficiencies<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">Undermethylation is frequently tied to deficiencies in key B vitamins that serve as methyl donors. These vitamins have independent roles in bone health:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Vitamin B12 &amp; Folate:<\/b><span style=\"font-weight: 400;\"> Low levels of these vitamins are strongly correlated with lower bone mineral density and a higher risk of hip fractures.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>MTHFR Mutations:<\/b><span style=\"font-weight: 400;\"> Genetic variants like <\/span><b>MTHFR C677T<\/b><span style=\"font-weight: 400;\"> can lead to undermethylation. Studies have shown that individuals with these variants may have a higher susceptibility to osteoporosis, particularly when their intake of folate and B12 is low.<\/span><\/li>\n<\/ul>\n<h3><b>Summary Table: Methylation and Bone Health<\/b><\/h3>\n<table>\n<tbody>\n<tr>\n<td><b>Mechanism<\/b><\/td>\n<td><b>Impact of Undermethylation<\/b><\/td>\n<td><b>Result<\/b><\/td>\n<\/tr>\n<tr>\n<td><b>Homocysteine<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Increases (Hyperhomocysteinemia)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Weakens collagen &amp; bone matrix<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>RANKL Gene<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Hypomethylated (Unsilenced)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Increases bone-destroying cells<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>Osteoblasts<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Reduced activity\/differentiation<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Slower new bone formation<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>Vitamin Co-factors<\/b><\/td>\n<td><span style=\"font-weight: 400;\">B12, Folate, and B6 are often low<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Decreased bone density<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h3><b>How to Monitor<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">If you are concerned about undermethylation affecting your bones, common clinical markers to check include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Homocysteine (Plasma):<\/b><span style=\"font-weight: 400;\"> Ideally kept below 8.0 or 9.0 umol\/L for optimal bone and cardiovascular health.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Serum B12 &amp; Folate:<\/b><span style=\"font-weight: 400;\"> To ensure the methylation cycle has the necessary raw materials.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>DEXA Scan:<\/b><span style=\"font-weight: 400;\"> To measure actual bone mineral density.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Ultimately, bone health is about much more than just calcium and Vitamin D; it is a delicate balance of cellular signaling and biochemical recycling. Addressing <\/span><b>undermethylation<\/b><span style=\"font-weight: 400;\"> allows you to tackle the biological root causes of bone degradation &#8211; like elevated homocysteine and overactive bone-resorbing cells &#8211; rather than just managing the symptoms of bone loss. By supporting your body\u2019s methylation cycle through targeted nutrition and lifestyle adjustments, you aren\u2019t just reinforcing your skeletal frame; you\u2019re optimizing the epigenetic &#8220;software&#8221; that governs your long-term vitality. Always consult with a healthcare professional to tailor a plan to your specific metabolic needs.<\/span><\/p>\n<p><a href=\"https:\/\/vitanetonline.com\/description\/N0494\/vitamins\/TMG-(Trimethylglycine)-1000-mg\/\"><img decoding=\"async\" class=\"aligncenter size-large\" src=\"https:\/\/vitanetonline.com\/images\/products\/0494_v5.jpg\" alt=\"TMG can boost Methyl Pools, and improve methylation!\" width=\"219\" height=\"400\" \/><\/a><\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Does Under-Methylation cause bone loss? Yes, undermethylation (or hypomethylation) can contribute to bone loss and an increased risk of osteoporosis. This happens through several biological pathways, most notably involving the buildup of homocysteine and the epigenetic regulation of bone cells. The link between poor methylation and bone health is primarily driven by three factors: 1. [&hellip;]<\/p>\n","protected":false},"author":10,"featured_media":23994,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_genesis_hide_title":false,"_genesis_hide_breadcrumbs":false,"_genesis_hide_singular_image":false,"_genesis_hide_footer_widgets":false,"_genesis_custom_body_class":"","_genesis_custom_post_class":"","_genesis_layout":"","footnotes":""},"categories":[909],"tags":[],"class_list":{"0":"post-23993","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-features","8":"entry"},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v21.3 (Yoast SEO v27.2) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>The Epigenetics of Osteoporosis: How Undermethylation Impacts Bone Density - Vitamins and Their Uses<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/vitamins.vitanetonline.com\/index.php\/the-epigenetics-of-osteoporosis-how-undermethylation-impacts-bone-density\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The Epigenetics of Osteoporosis: How Undermethylation Impacts Bone Density\" \/>\n<meta property=\"og:description\" content=\"Does Under-Methylation cause bone loss? Yes, undermethylation (or hypomethylation) can contribute to bone loss and an increased risk of osteoporosis. This happens through several biological pathways, most notably involving the buildup of homocysteine and the epigenetic regulation of bone cells. The link between poor methylation and bone health is primarily driven by three factors: 1. [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/vitamins.vitanetonline.com\/index.php\/the-epigenetics-of-osteoporosis-how-undermethylation-impacts-bone-density\/\" \/>\n<meta property=\"og:site_name\" content=\"Vitamins and Their Uses\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/VitaNetVitaminStore\/\" \/>\n<meta property=\"article:published_time\" content=\"2026-04-01T19:16:47+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/vitamins.vitanetonline.com\/wp-content\/uploads\/2026\/04\/undermethylationandboneloss-1024x559.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1024\" \/>\n\t<meta property=\"og:image:height\" content=\"559\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Darrell Miller\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@VitaNetLLC\" \/>\n<meta name=\"twitter:site\" content=\"@VitaNetLLC\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Darrell Miller\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/vitamins.vitanetonline.com\/index.php\/the-epigenetics-of-osteoporosis-how-undermethylation-impacts-bone-density\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/vitamins.vitanetonline.com\/index.php\/the-epigenetics-of-osteoporosis-how-undermethylation-impacts-bone-density\/\"},\"author\":{\"name\":\"Darrell Miller\",\"@id\":\"https:\/\/vitamins.vitanetonline.com\/#\/schema\/person\/31ebb9becbe2ea758ea5166c5d1d4301\"},\"headline\":\"The Epigenetics of Osteoporosis: How Undermethylation Impacts Bone Density\",\"datePublished\":\"2026-04-01T19:16:47+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/vitamins.vitanetonline.com\/index.php\/the-epigenetics-of-osteoporosis-how-undermethylation-impacts-bone-density\/\"},\"wordCount\":544,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/vitamins.vitanetonline.com\/#organization\"},\"image\":{\"@id\":\"https:\/\/vitamins.vitanetonline.com\/index.php\/the-epigenetics-of-osteoporosis-how-undermethylation-impacts-bone-density\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/vitamins.vitanetonline.com\/wp-content\/uploads\/2026\/04\/undermethylationandboneloss-scaled.png\",\"articleSection\":[\"Features\"],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/vitamins.vitanetonline.com\/index.php\/the-epigenetics-of-osteoporosis-how-undermethylation-impacts-bone-density\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/vitamins.vitanetonline.com\/index.php\/the-epigenetics-of-osteoporosis-how-undermethylation-impacts-bone-density\/\",\"url\":\"https:\/\/vitamins.vitanetonline.com\/index.php\/the-epigenetics-of-osteoporosis-how-undermethylation-impacts-bone-density\/\",\"name\":\"The Epigenetics of Osteoporosis: How Undermethylation Impacts Bone Density - Vitamins and Their Uses\",\"isPartOf\":{\"@id\":\"https:\/\/vitamins.vitanetonline.com\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/vitamins.vitanetonline.com\/index.php\/the-epigenetics-of-osteoporosis-how-undermethylation-impacts-bone-density\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/vitamins.vitanetonline.com\/index.php\/the-epigenetics-of-osteoporosis-how-undermethylation-impacts-bone-density\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/vitamins.vitanetonline.com\/wp-content\/uploads\/2026\/04\/undermethylationandboneloss-scaled.png\",\"datePublished\":\"2026-04-01T19:16:47+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/vitamins.vitanetonline.com\/index.php\/the-epigenetics-of-osteoporosis-how-undermethylation-impacts-bone-density\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/vitamins.vitanetonline.com\/index.php\/the-epigenetics-of-osteoporosis-how-undermethylation-impacts-bone-density\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/vitamins.vitanetonline.com\/index.php\/the-epigenetics-of-osteoporosis-how-undermethylation-impacts-bone-density\/#primaryimage\",\"url\":\"https:\/\/vitamins.vitanetonline.com\/wp-content\/uploads\/2026\/04\/undermethylationandboneloss-scaled.png\",\"contentUrl\":\"https:\/\/vitamins.vitanetonline.com\/wp-content\/uploads\/2026\/04\/undermethylationandboneloss-scaled.png\",\"width\":2560,\"height\":1396,\"caption\":\"Methylation plays a role in Bone building and Bone Loss!\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/vitamins.vitanetonline.com\/index.php\/the-epigenetics-of-osteoporosis-how-undermethylation-impacts-bone-density\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/vitamins.vitanetonline.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Features\",\"item\":\"https:\/\/vitamins.vitanetonline.com\/index.php\/category\/features\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"The Epigenetics of Osteoporosis: How Undermethylation Impacts Bone Density\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/vitamins.vitanetonline.com\/#website\",\"url\":\"https:\/\/vitamins.vitanetonline.com\/\",\"name\":\"Vitamins and Their Uses\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\/\/vitamins.vitanetonline.com\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/vitamins.vitanetonline.com\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/vitamins.vitanetonline.com\/#organization\",\"name\":\"VitaNet LLC\",\"url\":\"https:\/\/vitamins.vitanetonline.com\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/vitamins.vitanetonline.com\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/vitamins.vitanetonline.com\/wp-content\/uploads\/VitaNetLLC-Logo.png\",\"contentUrl\":\"https:\/\/vitamins.vitanetonline.com\/wp-content\/uploads\/VitaNetLLC-Logo.png\",\"width\":260,\"height\":90,\"caption\":\"VitaNet LLC\"},\"image\":{\"@id\":\"https:\/\/vitamins.vitanetonline.com\/#\/schema\/logo\/image\/\"},\"sameAs\":[\"https:\/\/www.facebook.com\/VitaNetVitaminStore\/\",\"https:\/\/x.com\/VitaNetLLC\",\"https:\/\/www.linkedin.com\/company\/vitanet-llc-health-food-store\"]},{\"@type\":\"Person\",\"@id\":\"https:\/\/vitamins.vitanetonline.com\/#\/schema\/person\/31ebb9becbe2ea758ea5166c5d1d4301\",\"name\":\"Darrell Miller\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/secure.gravatar.com\/avatar\/8ed3258b43aa0f4caa97a34d8375642a122af503d628af1965b07b8328a0f1ea?s=96&d=wavatar&r=g\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/8ed3258b43aa0f4caa97a34d8375642a122af503d628af1965b07b8328a0f1ea?s=96&d=wavatar&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/8ed3258b43aa0f4caa97a34d8375642a122af503d628af1965b07b8328a0f1ea?s=96&d=wavatar&r=g\",\"caption\":\"Darrell Miller\"},\"sameAs\":[\"https:\/\/vitanetonline.com\"],\"url\":\"https:\/\/vitamins.vitanetonline.com\/index.php\/author\/barrellm\/\"}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"The Epigenetics of Osteoporosis: How Undermethylation Impacts Bone Density - Vitamins and Their Uses","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/vitamins.vitanetonline.com\/index.php\/the-epigenetics-of-osteoporosis-how-undermethylation-impacts-bone-density\/","og_locale":"en_US","og_type":"article","og_title":"The Epigenetics of Osteoporosis: How Undermethylation Impacts Bone Density","og_description":"Does Under-Methylation cause bone loss? Yes, undermethylation (or hypomethylation) can contribute to bone loss and an increased risk of osteoporosis. This happens through several biological pathways, most notably involving the buildup of homocysteine and the epigenetic regulation of bone cells. The link between poor methylation and bone health is primarily driven by three factors: 1. [&hellip;]","og_url":"https:\/\/vitamins.vitanetonline.com\/index.php\/the-epigenetics-of-osteoporosis-how-undermethylation-impacts-bone-density\/","og_site_name":"Vitamins and Their Uses","article_publisher":"https:\/\/www.facebook.com\/VitaNetVitaminStore\/","article_published_time":"2026-04-01T19:16:47+00:00","og_image":[{"width":1024,"height":559,"url":"https:\/\/vitamins.vitanetonline.com\/wp-content\/uploads\/2026\/04\/undermethylationandboneloss-1024x559.png","type":"image\/png"}],"author":"Darrell Miller","twitter_card":"summary_large_image","twitter_creator":"@VitaNetLLC","twitter_site":"@VitaNetLLC","twitter_misc":{"Written by":"Darrell Miller","Est. reading time":"3 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/vitamins.vitanetonline.com\/index.php\/the-epigenetics-of-osteoporosis-how-undermethylation-impacts-bone-density\/#article","isPartOf":{"@id":"https:\/\/vitamins.vitanetonline.com\/index.php\/the-epigenetics-of-osteoporosis-how-undermethylation-impacts-bone-density\/"},"author":{"name":"Darrell Miller","@id":"https:\/\/vitamins.vitanetonline.com\/#\/schema\/person\/31ebb9becbe2ea758ea5166c5d1d4301"},"headline":"The Epigenetics of Osteoporosis: How Undermethylation Impacts Bone Density","datePublished":"2026-04-01T19:16:47+00:00","mainEntityOfPage":{"@id":"https:\/\/vitamins.vitanetonline.com\/index.php\/the-epigenetics-of-osteoporosis-how-undermethylation-impacts-bone-density\/"},"wordCount":544,"commentCount":0,"publisher":{"@id":"https:\/\/vitamins.vitanetonline.com\/#organization"},"image":{"@id":"https:\/\/vitamins.vitanetonline.com\/index.php\/the-epigenetics-of-osteoporosis-how-undermethylation-impacts-bone-density\/#primaryimage"},"thumbnailUrl":"https:\/\/vitamins.vitanetonline.com\/wp-content\/uploads\/2026\/04\/undermethylationandboneloss-scaled.png","articleSection":["Features"],"inLanguage":"en-US","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/vitamins.vitanetonline.com\/index.php\/the-epigenetics-of-osteoporosis-how-undermethylation-impacts-bone-density\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/vitamins.vitanetonline.com\/index.php\/the-epigenetics-of-osteoporosis-how-undermethylation-impacts-bone-density\/","url":"https:\/\/vitamins.vitanetonline.com\/index.php\/the-epigenetics-of-osteoporosis-how-undermethylation-impacts-bone-density\/","name":"The Epigenetics of Osteoporosis: How Undermethylation Impacts Bone Density - Vitamins and Their Uses","isPartOf":{"@id":"https:\/\/vitamins.vitanetonline.com\/#website"},"primaryImageOfPage":{"@id":"https:\/\/vitamins.vitanetonline.com\/index.php\/the-epigenetics-of-osteoporosis-how-undermethylation-impacts-bone-density\/#primaryimage"},"image":{"@id":"https:\/\/vitamins.vitanetonline.com\/index.php\/the-epigenetics-of-osteoporosis-how-undermethylation-impacts-bone-density\/#primaryimage"},"thumbnailUrl":"https:\/\/vitamins.vitanetonline.com\/wp-content\/uploads\/2026\/04\/undermethylationandboneloss-scaled.png","datePublished":"2026-04-01T19:16:47+00:00","breadcrumb":{"@id":"https:\/\/vitamins.vitanetonline.com\/index.php\/the-epigenetics-of-osteoporosis-how-undermethylation-impacts-bone-density\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/vitamins.vitanetonline.com\/index.php\/the-epigenetics-of-osteoporosis-how-undermethylation-impacts-bone-density\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/vitamins.vitanetonline.com\/index.php\/the-epigenetics-of-osteoporosis-how-undermethylation-impacts-bone-density\/#primaryimage","url":"https:\/\/vitamins.vitanetonline.com\/wp-content\/uploads\/2026\/04\/undermethylationandboneloss-scaled.png","contentUrl":"https:\/\/vitamins.vitanetonline.com\/wp-content\/uploads\/2026\/04\/undermethylationandboneloss-scaled.png","width":2560,"height":1396,"caption":"Methylation plays a role in Bone building and Bone Loss!"},{"@type":"BreadcrumbList","@id":"https:\/\/vitamins.vitanetonline.com\/index.php\/the-epigenetics-of-osteoporosis-how-undermethylation-impacts-bone-density\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/vitamins.vitanetonline.com\/"},{"@type":"ListItem","position":2,"name":"Features","item":"https:\/\/vitamins.vitanetonline.com\/index.php\/category\/features\/"},{"@type":"ListItem","position":3,"name":"The Epigenetics of Osteoporosis: How Undermethylation Impacts Bone Density"}]},{"@type":"WebSite","@id":"https:\/\/vitamins.vitanetonline.com\/#website","url":"https:\/\/vitamins.vitanetonline.com\/","name":"Vitamins and Their Uses","description":"","publisher":{"@id":"https:\/\/vitamins.vitanetonline.com\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/vitamins.vitanetonline.com\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/vitamins.vitanetonline.com\/#organization","name":"VitaNet LLC","url":"https:\/\/vitamins.vitanetonline.com\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/vitamins.vitanetonline.com\/#\/schema\/logo\/image\/","url":"https:\/\/vitamins.vitanetonline.com\/wp-content\/uploads\/VitaNetLLC-Logo.png","contentUrl":"https:\/\/vitamins.vitanetonline.com\/wp-content\/uploads\/VitaNetLLC-Logo.png","width":260,"height":90,"caption":"VitaNet LLC"},"image":{"@id":"https:\/\/vitamins.vitanetonline.com\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/VitaNetVitaminStore\/","https:\/\/x.com\/VitaNetLLC","https:\/\/www.linkedin.com\/company\/vitanet-llc-health-food-store"]},{"@type":"Person","@id":"https:\/\/vitamins.vitanetonline.com\/#\/schema\/person\/31ebb9becbe2ea758ea5166c5d1d4301","name":"Darrell Miller","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/secure.gravatar.com\/avatar\/8ed3258b43aa0f4caa97a34d8375642a122af503d628af1965b07b8328a0f1ea?s=96&d=wavatar&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/8ed3258b43aa0f4caa97a34d8375642a122af503d628af1965b07b8328a0f1ea?s=96&d=wavatar&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/8ed3258b43aa0f4caa97a34d8375642a122af503d628af1965b07b8328a0f1ea?s=96&d=wavatar&r=g","caption":"Darrell Miller"},"sameAs":["https:\/\/vitanetonline.com"],"url":"https:\/\/vitamins.vitanetonline.com\/index.php\/author\/barrellm\/"}]}},"_links":{"self":[{"href":"https:\/\/vitamins.vitanetonline.com\/index.php\/wp-json\/wp\/v2\/posts\/23993","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vitamins.vitanetonline.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/vitamins.vitanetonline.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/vitamins.vitanetonline.com\/index.php\/wp-json\/wp\/v2\/users\/10"}],"replies":[{"embeddable":true,"href":"https:\/\/vitamins.vitanetonline.com\/index.php\/wp-json\/wp\/v2\/comments?post=23993"}],"version-history":[{"count":1,"href":"https:\/\/vitamins.vitanetonline.com\/index.php\/wp-json\/wp\/v2\/posts\/23993\/revisions"}],"predecessor-version":[{"id":23995,"href":"https:\/\/vitamins.vitanetonline.com\/index.php\/wp-json\/wp\/v2\/posts\/23993\/revisions\/23995"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vitamins.vitanetonline.com\/index.php\/wp-json\/wp\/v2\/media\/23994"}],"wp:attachment":[{"href":"https:\/\/vitamins.vitanetonline.com\/index.php\/wp-json\/wp\/v2\/media?parent=23993"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/vitamins.vitanetonline.com\/index.php\/wp-json\/wp\/v2\/categories?post=23993"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/vitamins.vitanetonline.com\/index.php\/wp-json\/wp\/v2\/tags?post=23993"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}