P5P which stands for pyridoxal-5-phosphate is the most active component of vitamin B6. It is converted from three organic compounds, pyridoxal, pyridoxine and pyridoxamine. P5P B6 serves as a coenzyme to support certain enzymes in the body that play a crucial role in biosynthesis. It makes optimum use of vitamin B6 by facilitating body metabolism and other important biological processes.
Traditionally, vitamin B6 comes in the form of pyridoxine hydrochloride which the body cannot synthesize in its natural state. Pyridoxine hydrochloride must be processed and must be converted into pyridoxal-5-phosphate so that the body can effectively use vitamin B6.
Importance of P5P
P5P is used in the production of hemoglobin, histamine, and neurotransmitters and it also plays a key role in the metabolism of fats, amino acids, and glucose. Its enzymes trigger different types of amines and amino acids reaction by keeping carbon ions stable which gives them a very crucial role in the metabolism of cells. It has a vital role in the metabolism of amino acids. It helps convert methionine to cysteine and tryptophan to niacin. P5P is also used in gluconeogenesis or the production of glucose. It is an essential coenzyme in glycogenolysis, a process that occurs in the liver and muscles in reaction to the presence of glucagon or epinephrine.
Pyridoxal-5-phosphate is used to convert dopa, a substance used to treat Parkinson’s disease, into dopamine, a neurotransmitter that is produced in the brain and released by the hypothalamus. P5P converts glutamate into gamma-aminobutyric acid or GABA, a neurotransmitter that is found in the central nervous system of mammals.
Prevents blood clotting in the heart
It is used to treat irregular heart beat, a heart condition called arrhythmia. It is also used to treat myocardial infarction by preventing blood platelets, particularly glycoprotein IIb from sticking together which could cause the blood clot. P5P converts SAM-e into propylamine which is a precursor of polyamines. It also converts histidine to histamine by the process of decarboxylation. Also, it is believed to lower homocysteine levels caused by taking high amounts of methionine.