Short-chain fatty acids (SCFAs) - primarily butyrate, acetate, and propionate - are showing significant promise in research regarding nerve pain (neuropathic pain). While most studies are currently in the animal model stage, the mechanisms suggest they may play a dual role in both preventing and alleviating chronic pain. Primary Mechanisms for Nerve Pain Relief SCFAs influence the nervous system … [Read More...]
FEATURES

The NF-κB Pathway: How Butyrate “Turns Off” Disc Inflammation
Boosting butyrate through dietary fiber is a long game focused on systemic anti-inflammatory support. While research suggests butyrate has protective effects on intervertebral disc tissue, it is important to distinguish between “healing” a structural injury (like a herniated disc) and managing the localized inflammation that causes pain and prevents recovery. To maintain therapeutic levels of […]

How Your Immune System “Eats” a Herniated Disc (And How to Help It)
Dealing with a herniated (or “blown”) disc can be incredibly intense, especially when the pain radiates or causes weakness. The good news is that the body has a remarkable, natural mechanism for healing these injuries – often without the need for surgery. When a disc herniates, the soft inner material (the nucleus pulposus) pushes through […]

The Nightly Clean-Up: How Butyrate Calms Neuro-inflammation While You Sleep
Research from 2024 and 2025 increasingly identifies short-chain fatty acids (SCFAs) – particularly butyrate – as significant modulators of pain. While the field is still evolving, SCFAs appear to influence both the inflammatory and neurophysiological aspects of pain management through several distinct pathways. Mechanisms of Action SCFAs don’t just act as a energy source for […]

The Science of Spinal Longevity: Why Butyrate is a Game-Changer for Back Health
The connection between the gut and the spine is a rapidly emerging field of study known as the “Gut-Disc Axis” or the “Gut-Spinal Cord-Immune Axis.” Short-Chain Fatty Acids (SCFAs) – primarily acetate, propionate, and butyrate – act as the primary chemical messengers that bridge the gap between your microbiome and the health of your intervertebral […]

Why Your Microbiome Might Be the Reason You Can’t Sleep (And How to Fix It)
The relationship between the Short-Chain Fatty Acid (SCFA) butyrate and sleep is a fascinating look at the “gut-sleep axis.” When you consume prebiotic fibers that your gut bacteria ferment into butyrate, you aren’t just feeding your colon; you are sending biochemical signals that help reset your internal clock and balance the hormones that govern wakefulness. […]

Cellular Renewal From The Inside Out: The Power of Butyrate and IGF-1.
Insulin-like Growth Factor 1 (IGF-1) is a powerhouse hormone that serves as a primary mediator of growth hormone (GH) effects.1 While its role in building skeletal muscle and dense bone is well-known, its influence extends to nearly every system in the body, acting as a “master regenerator.”2 Recent research confirms a profound connection between the […]

Can Good Gut Health And SCFAs Help The Release of IGF-1?
Research indicates a strong connection between gut health and the production of Insulin-like Growth Factor 1 (IGF-1).1 This relationship is primarily mediated by the “gut-liver axis,” where the metabolites produced by a healthy microbiome – specifically Short-Chain Fatty Acids (SCFAs) – act as signaling molecules that trigger the systemic release of this vital growth hormone.2 […]

Why Akkermansia Loves Cayenne: Engineering a Healthier Gut Lining
Can Cayenne feed gut bacteria and support better cardiovascular health? Yes, cayenne pepper (specifically its active compound, capsaicin) provides significant support for both the cardiovascular system and the health of your gut microbiome.1 Cardiovascular Benefits Cayenne pepper is often referred to as a “circulatory stimulant” because of its rapid effect on blood flow.2 Research highlights […]

The Bitter Truth About Big Box Store Honey
The difference between local honey and “big box store” honey often comes down to two factors: processing and adulteration. While local honey is typically a raw, whole food, mass-produced honey is often treated as a commodity where consistency and cost-cutting are prioritized over nutritional value. 1. Why is Honey “Cut”? The primary reason big-box honey […]

Beyond the Beehive: How Honey Stimulates the Production of Butyrate and SCFAs
In general, pure honey uncut from the honeycomb does not cause gut dysbiosis; in fact, scientific evidence suggests it does the opposite. Rather than disrupting the microbiome, raw honey and honeycomb typically act as prebiotics, supporting the growth of beneficial bacteria while inhibiting pathogens.1 However, because honeycomb is a complex, raw food, there are specific […]
COMMENTARY

What You May Have Missed About Pure Cacao Powder
Recent research from late 2025 and early 2026 has introduced a few "missing pieces" that … [Read More...]

The Hidden Highway – The Gut-Lung Connection
Did you know your gut "talks" to your lungs? Most people have heard of the Gut-Brain … [Read More...]

SCFA Benefits For Organ Health!
Short-chain fatty acids (SCFAs)—primarily acetate, propionate, and butyrate—are the … [Read More...]

Interesting Facts about SCFAs that research has discovered in 2025 and 2026
Let’s dive into some of the most cutting-edge and obscure research from 2024 and 2025. 1. … [Read More...]

An Interesting Fact: The “double jeopardy” Relationship Between Alcohol And Your Gut.
The Fact: Alcohol Sabotages the Gut's "Repair Crew" The most fascinating - and damaging - … [Read More...]

An interesting fact that bridges the gap between your gut microbiome and renal function.
The Kidneys Can "Smell" Short-Chain Fatty Acids It sounds like science fiction, but your … [Read More...]

Interesting Fact: SCFAs act as an “Epigenetic Switches”
Yes, "SCFAs act as an "Epigenetic Switches" You might already know SCFAs (like butyrate) … [Read More...]

Toxic Water Contaminants Implicated in Parkinson’s Disease
The article on Dr. Mercola's website discusses a significant link between … [Read More...]

How Important is Magnesium for Optimal Health?
You may not think much about magnesium, but it is a very important mineral needed for … [Read More...]

Understanding the Benefits of Organic Acid-Free Coffee
If you’re a coffee lover, then you know that there’s nothing quite like a cup of freshly … [Read More...]


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